The replication suddenly stops for N minutes in version after version 10.4.15

SEMAPHORES

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OS WAIT ARRAY INFO: reservation count 440929294

--Thread 139722467284736 has waited at btr0cur.cc line 1492 for 60.00 seconds the semaphore:

SX-lock on RW-latch at 0x7ef2b8011158 created in file dict0dict.cc line 1954

a writer (thread id 139581332059904) has reserved it in mode  SX

number of readers 0, waiters flag 1, lock_word: 10000000

Last time write locked in file dict0stats.cc line 1968

OS WAIT ARRAY INFO: signal count 853851161

RW-shared spins 1894185518, rounds 11977859561, OS waits 89917364

RW-excl spins 928170891, rounds 6504095554, OS waits 24124968

RW-sx spins 18253227, rounds 252368118, OS waits 3117148

Spin rounds per wait: 6.32 RW-shared, 7.01 RW-excl, 13.83 RW-sx

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TRANSACTIONS

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Trx id counter 60395546748

Purge done for trx's n:o < 60395546744 undo n:o < 0 state: running but idle

History list length 67

LIST OF TRANSACTIONS FOR EACH SESSION:

---TRANSACTION 421197791234584, not started

0 lock struct(s), heap size 1128, 0 row lock(s)

---TRANSACTION 421197791230328, not started

0 lock struct(s), heap size 1128, 0 row lock(s)

---TRANSACTION 421197791226072, not started

0 lock struct(s), heap size 1128, 0 row lock(s)

---TRANSACTION 421197791179256, not started

0 lock struct(s), heap size 1128, 0 row lock(s)

---TRANSACTION 421197791217560, not started

0 lock struct(s), heap size 1128, 0 row lock(s)

---TRANSACTION 60395546745, ACTIVE (PREPARED) 60 sec

3 lock struct(s), heap size 1128, 1 row lock(s), undo log entries 2

MySQL thread id 12, OS thread handle 139722802640640, query id 9925262534 Waiting for prior transaction to commit

---TRANSACTION 60395546740, ACTIVE (PREPARED) 60 sec

3 lock struct(s), heap size 1128, 1 row lock(s), undo log entries 2

MySQL thread id 14, OS thread handle 139722468513536, query id 9925262528 Waiting for prior transaction to commit

---TRANSACTION 60395546737, ACTIVE 60 sec updating or deleting

mysql tables in use 1, locked 1

2 lock struct(s), heap size 1128, 1 row lock(s)

MySQL thread id 18, OS thread handle 139722467284736, query id 9925262524 Update_rows_log_event::ha_update_row(-1)

UPDATE tableName

            SET `column` = '[1,2,3,4,5]', `updatedAt` = '2021-02-03T14:54:28Z'

            WHERE id = 1234

---TRANSACTION 60395546747, ACTIVE (PREPARED) 60 sec

3 lock struct(s), heap size 1128, 1 row lock(s), undo log entries 2

MySQL thread id 19, OS thread handle 139581271136000, query id 9925262538 Waiting for prior transaction to commit

---TRANSACTION 60395546746, ACTIVE (PREPARED) 60 sec

3 lock struct(s), heap size 1128, 1 row lock(s), undo log entries 2

MySQL thread id 13, OS thread handle 139722468820736, query id 9925262537 Waiting for prior transaction to commit

---TRANSACTION 60395546741, ACTIVE (PREPARED) 60 sec

3 lock struct(s), heap size 1128, 1 row lock(s), undo log entries 2

MySQL thread id 17, OS thread handle 139722467591936, query id 9925262530 Waiting for prior transaction to commit

---TRANSACTION 60395546744, ACTIVE (PREPARED) 60 sec

3 lock struct(s), heap size 1128, 1 row lock(s), undo log entries 2

MySQL thread id 15, OS thread handle 139722468206336, query id 9925262532 Waiting for prior transaction to commit

---TRANSACTION 60395546739, ACTIVE (PREPARED) 60 sec

3 lock struct(s), heap size 1128, 1 row lock(s), undo log entries 2

MySQL thread id 16, OS thread handle 139722467899136, query id 9925262526 Waiting for prior transaction to commit

---TRANSACTION 421197791175000, not started

0 lock struct(s), heap size 1128, 0 row lock(s)

---TRANSACTION 421197791170744, not started

0 lock struct(s), heap size 1128, 0 row lock(s)