all queries get stuck until a timeout occurs on all of them

~$ my_print_defaults  --mysqld

--user=mysql

--pid-file=/run/mysqld/mysqld.pid

--socket=/run/mysqld/mysqld.sock

--basedir=/usr

--datadir=/var/lib/mysql

--tmpdir=/tmp

--lc-messages-dir=/usr/share/mysql

--bind-address=0.0.0.0

--key_buffer_size=64M

--max_allowed_packet=1G

--max_connections=300

--query_cache_size=0

--log_error=/var/log/mysql/error.log

--expire_logs_days=10

--character-set-server=utf8mb4

--collation-server=utf8mb4_general_ci

--query_cache_size=0

--query_cache_type=0

--query_cache_limit=0

--join_buffer_size=512K

--tmp_table_size=128M

--max_heap_table_size=128M

--innodb_buffer_pool_size=32G

--innodb_buffer_pool_instances=16

--innodb_log_file_size=4G

--optimizer_use_condition_selectivity=1

--optimizer_switch=optimize_join_buffer_size=on

--in_predicate_conversion_threshold=4294967295

--innodb_data_home_dir=/var/lib/mysql/

--innodb_data_file_path=ibdata1:10M:autoextend

--innodb_log_group_home_dir=/var/lib/mysql/

--innodb_lock_wait_timeout=50

--innodb_file_per_table=1

--innodb_log_buffer_size=4M

--performance_schema

--optimizer_switch=rowid_filter=off

--optimizer_use_condition_selectivity=1

--optimizer_search_depth=0

--slow_query_log

--slow_query_log_file=/var/log/mysql/mariadb-slow.log

--long_query_time=20.0

--innodb_print_all_deadlocks=1

--lock_wait_timeout=240

--bind-address=0.0.0.0

--sql_mode=

--local-infile=0

--innodb_open_files=4000

--table_open_cache=3000

--table_definition_cache=3000