MariaDB becomes often unresponsive

2018-03-23  8:32:43 140401445676800 [Warning] InnoDB: A long semaphore wait:

--Thread 140401323267840 has waited at row0row.cc line 988 for 241.00 seconds the semaphore:

S-lock on RW-latch at 0x7fbb5ed79b18 created in file buf0buf.cc line 1471

a writer (thread id 140401340053248) has reserved it in mode  exclusive

number of readers 0, waiters flag 1, lock_word: ffffffffdfffffff

Last time read locked in file row0row.cc line 988

Last time write locked in file btr0cur.cc line 1917

2018-03-23  8:32:43 140401445676800 [Warning] InnoDB: A long semaphore wait:

--Thread 140401340053248 has waited at btr0cur.cc line 1917 for 241.00 seconds the semaphore:

X-lock (wait_ex) on RW-latch at 0x7fbd21a936a0 created in file buf0buf.cc line 1471

a writer (thread id 140401340053248) has reserved it in mode  wait exclusive

number of readers 1, waiters flag 0, lock_word: ffffffffffffffff

Last time read locked in file row0row.cc line 988

Last time write locked in file buf0flu.cc line 1236

2018-03-23  8:32:43 140401445676800 [Warning] InnoDB: A long semaphore wait:

--Thread 140400859473664 has waited at row0ins.cc line 1926 for 241.00 seconds the semaphore:

S-lock on RW-latch at 0x55b134618c50 created in file dict0dict.cc line 1107

a writer (thread id 140401408464640) has reserved it in mode  wait exclusive

number of readers 3, waiters flag 1, lock_word: fffffffffffffffd

Last time read locked in file row0ins.cc line 1926

Last time write locked in file row0mysql.cc line 3383

2018-03-23  8:32:43 140401445676800 [Warning] InnoDB: A long semaphore wait:

--Thread 140401314875136 has waited at row0purge.cc line 853 for 241.00 seconds the semaphore:

S-lock on RW-latch at 0x55b134618c50 created in file dict0dict.cc line 1107

a writer (thread id 140401408464640) has reserved it in mode  wait exclusive

number of readers 3, waiters flag 1, lock_word: fffffffffffffffd

Last time read locked in file row0ins.cc line 1926

Last time write locked in file row0mysql.cc line 3383

2018-03-23  8:32:43 140401445676800 [Warning] InnoDB: A long semaphore wait:

--Thread 140401331660544 has waited at fsp0fsp.cc line 2821 for 241.00 seconds the semaphore:

X-lock on RW-latch at 0x55b1345efe40 created in file fil0fil.cc line 1551

a writer (thread id 140401340053248) has reserved it in mode  exclusive

number of readers 0, waiters flag 1, lock_word: 0

Last time read locked in file not yet reserved line 0

Last time write locked in file fsp0fsp.cc line 2821

2018-03-23  8:32:43 140401445676800 [Warning] InnoDB: A long semaphore wait:

--Thread 140401408464640 has waited at row0mysql.cc line 3383 for 241.00 seconds the semaphore:

X-lock (wait_ex) on RW-latch at 0x55b134618c50 created in file dict0dict.cc line 1107

a writer (thread id 140401408464640) has reserved it in mode  wait exclusive

number of readers 3, waiters flag 1, lock_word: fffffffffffffffd

Last time read locked in file row0ins.cc line 1926

Last time write locked in file row0mysql.cc line 3383

2018-03-23  8:32:43 140401445676800 [Warning] InnoDB: A long semaphore wait:

--Thread 140400655324928 has waited at row0ins.cc line 1926 for 241.00 seconds the semaphore:

S-lock on RW-latch at 0x55b134618c50 created in file dict0dict.cc line 1107

a writer (thread id 140401408464640) has reserved it in mode  wait exclusive

number of readers 3, waiters flag 1, lock_word: fffffffffffffffd

Last time read locked in file row0ins.cc line 1926

Last time write locked in file row0mysql.cc line 3383

2018-03-23  8:32:43 140401445676800 [Warning] InnoDB: A long semaphore wait:

--Thread 140400030902016 has waited at row0mysql.cc line 1783 for 241.00 seconds the semaphore:

S-lock on RW-latch at 0x55b134618c50 created in file dict0dict.cc line 1107

a writer (thread id 140401408464640) has reserved it in mode  wait exclusive

number of readers 3, waiters flag 1, lock_word: fffffffffffffffd

Last time read locked in file row0ins.cc line 1926

Last time write locked in file row0mysql.cc line 3383

2018-03-23  8:32:43 140401445676800 [Warning] InnoDB: A long semaphore wait:

--Thread 140400016656128 has waited at row0ins.cc line 1926 for 241.00 seconds the semaphore:

S-lock on RW-latch at 0x55b134618c50 created in file dict0dict.cc line 1107

a writer (thread id 140401408464640) has reserved it in mode  wait exclusive

number of readers 3, waiters flag 1, lock_word: fffffffffffffffd

Last time read locked in file row0ins.cc line 1926

Last time write locked in file row0mysql.cc line 3383

2018-03-23  8:32:43 140401445676800 [Note] InnoDB: A semaphore wait:

--Thread 140400038479616 has waited at row0upd.cc line 183 for 150.00 seconds the semaphore:

S-lock on RW-latch at 0x55b134618c50 created in file dict0dict.cc line 1107

a writer (thread id 140401408464640) has reserved it in mode  wait exclusive

number of readers 3, waiters flag 1, lock_word: fffffffffffffffd

Last time read locked in file row0ins.cc line 1926

Last time write locked in file row0mysql.cc line 3383

2018-03-23  8:32:43 140401445676800 [Note] InnoDB: A semaphore wait:

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