Using SET multiple times on the same variable fails.

Setting optimizer_switch twice only sets the later value:

set statement optimizer_switch="index_merge=off", optimizer_switch="index_merge_sort_union=off" FOR select @@optimizer_switch;

index_merge=on,index_merge_union=on,index_merge_sort_union=off,index_merge_intersection=on,index_merge_sort_intersection=off,engine_condition_pushdown=off,index_condition_pushdown=on,derived_merge=on,derived_with_keys=on,firstmatch=on,loosescan=on,materialization=on,in_to_exists=on,semijoin=on,partial_match_rowid_merge=on,partial_match_table_scan=on,subquery_cache=on,mrr=off,mrr_cost_based=off,mrr_sort_keys=off,outer_join_with_cache=on,semijoin_with_cache=on,join_cache_incremental=on,join_cache_hashed=on,join_cache_bka=on,optimize_join_buffer_size=off,table_elimination=on,extended_keys=on,exists_to_in=on