Is there any adverse effect if READ_ONLY ADMIN privilege is taken away from the root user?

This is just a question, a user story.

It turns out, that when running mysql_upgrade on an older server version where ALL PRIVILEGES and the SUPER privilege still included the READ_ONLY ADMIN privilege, the READ_ONLY ADMIN privilege is kept for these users.

It caused an accidental problem, because it allowed a replica to be changed manually, which then broke replication due to a PK violation.

Anyway, my question here is: does taking away the READ_ONLY ADMIN privilege from the root user cause any subtle issues?

I already discovered that by taking this privilege away, the root user cannot give it back to itself:
REVOKE READ_ONLY ADMIN ON . FROM 'root'@'localhost';

GRANT READ_ONLY ADMIN ON . TO 'root'@'localhost';
results in
ERROR 1698 (28000): Access denied for user 'root'@'localhost'

the same error occurs for
GRANT ALL PRIVILEGES ON . FROM 'root'@'localhost';