Might be just me, but in contrast to 10.3 I couldn't make 10.4 work with:
thread-handling=pool-of-threads
the database doesn't seem to start... Even a newly setup database with mysql_install_db. Only when I removed that line, the database was running. Sorry that I can't give any more info. I have only one production 10.4 server cluster available and I'm very happy, that it's finally running so I don't want to sacrifice it for experiments.
Nevertheless, I'm just saying perhaps you might want to double-check this whether it really works. Otherwise feel free to close this as Works-For-Me. I'm on Ubuntu Disco with 10.4.6. Thank you 
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Bug
Blocker