Replica with GTID stopping replication on some transactions when no gtid replica didn't stop

We have had replication stop on our GTID enabled slave when the same events are passing through
Things such as this have failed and skip has been executed to allow replication to continue

Last_Errno: 1396
Last_Error: Error 'Operation CREATE USER failed for 'user1'@'192.168.x.xx'' on query. Default database: 'information_schema'. Query: 'CREATE USER ''user1'@'192.168.x.xx''
Actual user details changed for security reasons

Drop user has stalled and a error from what I believe to be a stored procedure which inserts some records into a table has caused issues.