We could implement a black list to query cache

SELECT * FROM schema.table

an idea is a "mysql.query_cache_deny_tables" table with four columns:

SCHEMA varchar(64), 

TYPE enum ('=','LIKE')

TABLE  varchar(255)

PARTITION varchar(255)

PRIMARY KEY (SCHEMA,TYPE,TABLE,PARTITION) BTREE (usefull with LIKE)

we could check if table being cache is inside this table with 2 queries:
1) type="="

SELECT 1

FROM mysql_query_cache_deny_tables 

WHERE 

SCHEMA="#table_schema#" AND 

TYPE="=" AND 

TABLE_LIKE IN ("#table_name#","") AND 

PARTITION IN ("#partition#",'')

LIMIT 1

2) type="LIKE"

SELECT 1 

FROM mysql_query_cache_deny_tables 

WHERE 

SCHEMA="#table_schema#" AND 

TYPE="LIKE" AND 

"#table_name#" LIKE TABLE AND 

"#partition_name#" LIKE PARTITION

LIMIT 1

if this query return any rows we discart the query cache
table ="" => don't cache any table from this SCHEMA,
partition ="" => table without partitions or all partitions of this table

obvious more rows inside this table = slower query cache, must check what's fast, a "table "LIKE field, or a hash table with many "=" conditions and no "like" condition

maybe we could add two others types: "!=" and "NOT LIKE"