[Upgrade 10.1.25-MariaDB] Lose index from large table

• When i run "yum update", MariaDB upgrade from 10.0.* to 10.1.25
• TokuDB (5.6 not upgrade)
• Small Problem:

• Can't start service mariadb, folder source on "/home/mariadb". I fixed by "ProtectHome: Off"

• Big Problem:

• Table engine TokuDB, with large data > 300GB
• When query select with too slow, i checked indexes of table. it's has indexes (A,B) for select query
• I explained query, It's normal with indexes
• BUT query return large rows

• Example with one query before, after upgrade:
• Normal (not upgrade): 10000 rows
• BUT (upgraded): 1000,000 rows
• Then server slow down.

Please help me.
Many thanks